Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp WavesDendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves

B Chiovini, GF Turi, G Katona, A Kaszas, D Palfi, P Maak, G Szalay, MF Szabo, G Szabo, Z Szadai, S Kali, B Rozsa

Neuron 2014

Chiovini et al, Neuron (2014)

Using fast 3D two-photon imaging (Femto3D-AO) in combination with electrophysiological recordings and a caged glutamate compound (DNI-Glu-TFA), Chiovini et al demonstrated that a single activation of clustered glutamatergic inputs in the distal dendrites of FS-PV INs, which generate a depolarizing hump and reproduce the hot spots associated with spontaneous SPW-R events, is capable of generating secondary membrane oscillations in the ripple frequency range.

Chiovini et al, Neuron (2014)


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Tags: 3D two-photon