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Voltage Imaging with the FEMTO3D Atlas

KEEPING UP WITH ACTION POTENTIALS: VOLTAGE IMAGING WITH THE FEMTO3D ATLAS

Voltage sensors, combined with the achievable 100kHz sampling rate of the FEMTO3D Atlas, are capable of detecting ultrafast transients, such as action potentials. The FEMTO3DAtlas, equipped with the AO technology and our real-time motion correction feature, is currently the only scanning device which can keep up with the speed of firing neurons!

The rapidly evolving voltage sensor technology will determine the next decade of bioimaging.Ā TheseĀ molecules have faster kinetics than calcium sensors and can provide superior temporal resolution, capable of differentiating individual action potentials even within bursts.

Fast evolving voltage sensors, combined with the impressive 100kHz sampling rate of the FEMTO3D Atlas acousto-optic (AO) two-photon microscope, are suited for detecting ultrafast transients, such as action potentials in a scanning volume of a cubic millimeter. The Atlas, powered by the AO technology, is currently the only imaging device that can keep up with the speed of firing neurons during complex, in vivo behavioral experiments. Moreover, the novel Femtonics FocusPinner real-time 3D motion correction feature eliminates motion artifacts in real time, and provides an unprecedented signal-to-noise ratio!

The investigation of neuronal circuit mechanisms requires experimental approaches that give access to the electrical activities of a high number of neurons across a large volume of brain tissue with a temporal resolution consistent with the millisecond timescale of synaptic communication. Our technology makes it possible: contact our team to learn more!

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