Highlighted publications
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions
24th February 2022
Local circuit amplification of spatial selectivity in the hippocampus
01st December 2021
Theoretical Design, Synthesis, and In Vitro Neurobiological Applications of a Highly Efficient Two-Photon Caged GABA Validated on an Epileptic Case
03rd June 2021
B. Chiovini, D. Pálfi, M. Majoros, G. Juhász, G. Szalay, G. Katona, M. Szőri, O. Frigyesi, Cs. Lukácsné Haveland, G. Szabó, F. Erdélyi, Z. Máté, Z. Szadai, M. Madarász, M. Dékány, I. G. Csizmadia, E. Kovács, B. Rózsa, and Z. Mucsi
Two-photon GCaMP6f imaging of infrared neural stimulation evoked calcium signals in mouse cortical neurons in vivo
07th May 2021
A. Kaszas, G. Szalay, A. Slézia, A. Bojdán, I. Vanzetta, B. Hangya, B. Rózsa, R. O’Connor & D. Moreau
Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice
05th October 2020
T. Geiller, B. Vancura, S. Terada, E. Troullinou, S. Chavlis, G. Tsagkatakis, P. Tsakalides, K. Ócsai, P. Poirazi, B. J. Rózsa, A. Losonczy
Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution
05th October 2020
C. S. Cowan, M. Renner, M. De Gennaro, B. Gross-Scherf, D.Goldblum, Y. Hou, M. Munz, T. M. Rodrigues, J. Krol, T. Szikra, R. Cuttat, A. Waldt, P. Papasaikas, R. Diggelmann, C. P. Patino-Alvarez, P. Galliker, S. E. Spirig, D. Pavlinic, N. Gerber-Hollbach, S. Schuierer, A. Srdanovic, M. Balogh, R. Panero, A. Kusnyerik, A. Szabo, M. B. Stadler, S. Orgül, S. Picelli, P. W. Hasler, A. Hierlemann, H. P. N. Scholl, G. Roma, F. Nigsch, B. Roska
Restoring light sensitivity using tunable near-infrared sensors
05th June 2020
D. Nelidova, R. K. Morikawa, C. S. Cowan, Z. Raics, D. Goldblum, H. P. N. Scholl, T. Szikra, A. Szabo, D. Hillier, B. Roska
Dendritic action potentials and computation in human layer 2/3 cortical neurons
03rd January 2020
A. Gidon, T. A. Zolnik, P. Fidzinski, F. Bolduan, A. Papoutsi, P. Poirazi, M. Holtkamp, I. Vida, M. E. Larkum
High and asymmetric somato-dendritic coupling of V1 layer 5 neurons independent of visual stimulation and locomotion
27th December 2019
V. Francioni, Z. Padamsey, N. L Rochefort
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
31st January 2020
Cs. Cserép, B. Pósfai, N. Lénárt, R. Fekete, Zs. I. László, Zs. Lele, B. Orsolits, G. Molnár, S. Heindl, A. D. Schwarcz, K. Ujvári, Zs. Környei, K. Tóth, E. Szabadits, B. Sperlágh, M. Baranyi, L. Csiba, T. Hortobágyi, Zs. Maglóczky, B. Martinecz, G. Szabó, F. Erdélyi, R. Szipőcs, M. M. Tamkun, B. Gesierich, M. Duering, I. Katona, A. Liesz, G. Tamás, Á. Dénes
Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
03rd May 2016
G. Szalay, B. Martinecz, N. Lénárt, Zs. Környei, B. Orsolits, L. Judák, E. Császár, R. Fekete, B. L. West, G. Katona, B. Rózsa & Á. Dénes
Fast 3D Imaging of Spine, Dendritic, and Neuronal Assemblies in Behaving Animals
01st August 2016
G. Szalay, L. Judak, G. Katona, K. Ocsai, G. Juhasz, M. Veress, Z. Szadai, A. Feher, T. Tompa, B. Chiovini, P. Maak, B. Rozsa
Electrical behaviour of dendritic spines as revealed by voltage imaging
05th October 2015
M. A. Popovic, N. Carnevale, B. Rozsa & D. Zecevic
Time-Resolved Imaging Reveals Heterogeneous Landscapes of Nanomolar Ca2+ in Neurons and Astroglia
21st October 2015
Single-cell–initiated monosynaptic tracing reveals layer-specific cortical network modules
03rd July 2015
Combined two-photon imaging, electrophysiological, and anatomical investigation of the human neocortex in vitro
11th September 2014
B. P. Kerekes, K. Toth, A. Kaszas, B. Chiovini, Z. Szadai, G. Szalay, D. Palfi, A. Bago, K. Spitzer, B. Rozsa, I. Ulbert, L. Wittner
Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves
21st May 2014
Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes
08th January 2012
G. Katona, G. Szalay, P. Maák, A. Kaszás, M. Veress, D. Hillier, B. Chiovini, E. S. Vizi, B. Roska & B. Rózsa
Local circuit amplification of spatial selectivity in the hippocampus
Tristan Geiller, Sadra Sadeh, Sebastian V. Rolotti, Heike Blockus, Bert Vancura, Adrian Negrean, Andrew J. Murray, Balázs Rózsa, Franck Polleux, Claudia Clopath & Attila Losonczy
01st December 2021
A recently published breakthrough Nature paper upends decades of dogma about memory storage and formation in the hippocampus.
Place cells, the pyramidal neurons responsible for constructing and maintaining cognitive maps, create sparse networks in the hippocampus. As scientists usually investigate the activity of either single neurons, or brain regions consisting of large amounts of cells, much remains unknown about small circuits of place cells linked together in intimate conversation. For the first time, Geiller et al. from the team of Attila Losonczy (Professor of Neuroscience at Columbia University) have developed a method to not only detect the activity of individual hippocampal place cells forming spatial maps in real time, but also that of all the neurons connected to them: including excitatory neurons and inhibitory interneurons.
This exceptional feat would not have been possible without combining cutting-edge techniques and lab tools, one of which is the FEMTO3D Atlas acousto-optic two-photon microscope, which can target and follow 3D networks of sparsely distributed neurons even in deep brain regions simultaneously, with high SNR. With this tool in hand, the team has made the dogma-defying discovery that neurons in the memory center of the brain are much more connected than previously thought. They learn collaboratively in local groups, storing information redundantly – similarly to holograms. Ultimately, a better understanding of the fundamentals of how memories are formed can lead to better treatments for conditions associated with memory problems.
Read the whole article here.
